上海第二医科大学生物化学和分子生物学教研室人类基因治疗研究中心,上海 200025

摘 要:摘 要:Bcl-2家族蛋白质在细胞凋亡的调控机制中起着重要的作用,该家族包括唯BH3结构域的蛋白质(only BH3 domain protein),如Bid、Bik、Puma、Nova、Bmf等。随着凋亡研究的深入,在哺乳动物中现已发现10多种唯BH3结构域的蛋白质,并且在凋亡中发挥重要的作用。本文主要论述唯BH3域蛋白的作用机制及其应用的研究进展。

Advance in research on BH3 -only protein of Bcl-2 family
ZHAO Xiao-Ping, QIAN Guan-Xiang*
The Research Center of Human Gene Therapy, Department of Biochemistry and Molecular Biology, Shanghai Second Medical University, Shanghai 200025, China

Abstract: Abstract: Apoptosis is the physiological process used by an organism to selectively eliminate cells that are no longer needed, or have been damaged, or are dangerous. A central role in the control of apoptosis is played by the Bcl-2 family of proteins.This family includes a kind of protein which has only BH3 domain, such as Bid,Bik,Puma,Bmf and so on.Now researchers have found more than ten kinds of only BH3 domain protein.Meanwhile,these proteins are key members in Bcl-2 family to regulate apoptosis.
Key words: apoptosis;BH3 domain;mitochondria

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