《生命科学》 2023, 35(3): 267-276
通讯作者：孙 逊 , Email:email@example.com
Using bacteria as a treatment for cancers has a long history. With the continuous exploration of the tumor microenvironment and immune system, bacterial therapy develops into a platform technology, which opens up new strategies and potentials for medical immunotherapy. Depending on their own characteristics, certain bacteria specifically target tumor tissues, directly inhibit tumor growth, and also stimulate both innate and adaptive immune responses, thus significantly improving the antitumor efficacy and even helping to solve severe problems such as metastatic tumors. Through genetic engineering technology, the molecular mechanism of bacteria can be regulated at the gene level to customize their biological function, and various therapeutic immuno-agents can be efficiently delivered into the tumor lesions, so as to achieve the purpose of precise regulation and effective activation, of which is unmatched by other drug delivery systems. In addition, the tumor-targeted bacteria-mediated treatment can be used either as monotherapy or in combination with other treatment modalities such as chemotherapy, radiotherapy, and photothermal therapy to gain more promising clinical results. This review mainly discusses the key to the tumor-targeting and antitumor immune effects of live bacteria, summarizes the related studies of bioengineered bacteria for immunotherapy and their advantages when cooperated with other therapeutic modalities, thereby providing a basis for the further research and development of bacterial therapy.
Communication Author：SUN Xun , Email:firstname.lastname@example.org