《生命科学》 2023, 35(3): 252-266
通讯作者：华子春 , Email:firstname.lastname@example.org
Bacteria-mediated tumor therapy can be traced back to more than one century ago. Its characteristic of intratumoral colonization and proliferation with high targeting capacity is unachievable by traditional tumor therapies, such as radiotherapy and immune checkpoint modulation. In recent years, with the development of synthetic biology, this therapy has been greatly developed, and a variety of antitumor strains represented by Salmonella have been found. This paper reviews the construction of attenuated Salmonella strains based on a modification strategy that balances bacterial antitumor efficacy and virulence, as well as the current status and development of attenuated strains as drug delivery vehicles mediating oncogene therapy.
Communication Author：HUA Zi-Chun , Email:email@example.com