《生命科学》 2022, 34(12): 1485-1492
通讯作者：祁 俊 , Email:email@example.com
Acute and chronic skin wounds are clinically common, with large individual differences, and the treatment of chronic wounds is more difficult. In addition, skin fibrosis related diseases have grown immensely, while existing treatment modalities are less effective. Therefore, there is a great need to find a new treatment strategy for skin wounds and fibrosis. Adenosine plays an important role in wound healing and tissue repair processes, and adenosine can inhibit inflammatory responses, promote angiogenesis, and promote collagen synthesis to accelerate wound healing by activating its receptors. However, excessive activation of adenosine receptors can also stimulate abnormal proliferation of fibroblasts and collagen to mediate dermal fibrogenesis. This review focuses on the roles of adenosine and its receptors in skin wound healing and fibrosis, which will hopefully provide some ideas and applications for the regenerative medicine treatment strategies.
Communication Author：QI Jun , Email:firstname.lastname@example.org