《生命科学》 2022, 34(4): 459-467
通讯作者：于 彬 , Email:email@example.com
Malignancy is a great threat to human lives and health. Biotherapy has already become one of the safe and effective means for treatment of malignancies. Oncolytic adenovirus has attracted extensive attention as a potential biological anti-tumor carrier, which can selectively destroy tumor cells and produce cascade reactions, simultaneously releasing cytokines and tumor antigens to stimulate systemic antitumor immunity. However, there are still some limitations in the application and practice of oncolytic adenovirus in humans, such as pre-existing immunity, liver enrichment by intravenous injection, and insufficient targeting, which reduce the infection efficiency and anti-tumor activity of the virus. In this paper, the construction and application of oncolytic adenovirus were introduced, the research on enhancing tumor targeting and killing activity of oncolytic adenovirus through structural modification of the capsid protein was summarized, combining with their research achievements, in order to provide references for the design and application of oncolytic adenovirus.
Communication Author：YU Bin , Email:firstname.lastname@example.org