摘 要：摘 要：去甲肾上腺素和肾上腺素受体在大鼠中枢神经系统(CNS)的发育早期开始表达，且受体表达的时空模式与脑发育过程中某些脑区神经元的迁移和分化相一致，这提示去甲肾上腺素在中枢神经系统的发育中具有重要作用。本文论述了胚胎和新出生的大鼠不同脑区肾上腺素受体mRNA的表达模式以及这些受体对体外培养的成熟细胞和相应的前体细胞的调控效应，通过离体和在体研究的实验证据，阐述肾上腺素受体介导了去甲肾上腺素对神经前体细胞的增殖、生长、迁移、分化和存活的调控作用。进一步明确了去甲肾上腺素在CNS发育中所起的作用，使其可作为成体脑修复的助动剂而赋予新的意义。
Abstract: Abstract: Noradrenaline and adrenoreceptors are early present in the developing central nervous system of rat.The temporal and spatial distribution of adrenoreceptors in developing brain is consistent with migration and differentiation of neurons in some brain areas. These findings suggest that adrenoreceptors may mediate a neurotrophic effect of noradrenaline during the development of fetal central nervous system. The present review focuses on the pattern of adrenoreceptor mRNA expression in specific embroyonic and neonatal brain regions and the developmental regulation of adrenoreceptor on cultured mature and corresponding progenitor cells of rat CNS. in vitro and in vivo data illuminate that adrenoreceptor could play roles in proliferation, growth, migration, differentiation and survival of neural precursor cells. The understanding of noradrenaline function during early neural maturation could lead to the development of pharmacological tools aiming at improving adult brain repairing strategies.
Key words: adrenoreceptor ; development ; central nervous system; noradrenaline