复旦大学上海医学院免疫学系 教育部分子医学重点实验室 上海基因免疫与疫苗研究中心,上海 200032

摘 要:摘 要:CCL27是一种CC型趋化因子,其配体为CCR10。由于mRNA剪切的不同,CCL27形成两种不同的分子,即经典CCL27和其变异体PESKY,前者含分泌肽,对活化CD4+T细胞有趋化作用,是皮肤炎症反应中扮演主要角色的趋化因子;后者含有核内定位序列,调控细胞骨架结构的重排,这一特性为该趋化因子所独有,可能预示着趋化因子家族的新功能。

Differential splicing mechanism of CCL27 and distinct consequence
SHAO Xian-An, XIONG Si-Dong*
Department of Immunology of Shanghai Medical College of Fudan University, Key Laboratory of Molecular Medicine of Ministry of Education, Center for Gene Immunization and Vaccine Research, Shanghai 200032, China

Abstract: Abstract: CC chemokine ligand 27 (CCL27), through interaction with its cognate receptor, CC chemokine receptor 10 (CCR10), involved in attracting a subset of CD4+ T cells to the skin during some cutaneous inflammatory responses. Strangely, CCL27 can also be produced as a non-secreted form, as a result of alternative splicing. This protein, termed PESKY, is targeted to the nucleus where it is able to modulate transcription and alter cell morphology. Specifically, PESKY induces a rearrangement of the actin cytoskeleton. Such character is sole in chemokine family and may foreshow new function of chemokine in immune response.
Key words: CCL27; PESKY; splicing mechanism; function

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