《生命科学》 2021, 33(9): 1096-1103
通讯作者：陈 巍 , Email:email@example.com
In recent years, many brain health problems, such as Alzheimer's disease, Parkinson's disease, depression and obesity caused by central nervous system dysfunction, have received wide attention. Endocannabinoids are a class of important neuromodulators and key active factors regulating energy homeostasis in the brain. They are closely related to the occurrence and development of many neurodegenerative diseases and brain health problems, and are regarded as potential intervention targets for many central nervous system dysfunctions. A large number of studies have shown that regular exercise can effectively improve or alleviate the dysfunction of central nervous system, reduce the risk of Alzheimer's disease, Parkinson's disease, depression and obesity, and plays a positive role in promoting the brain health, whilst endocannabinoid system may be involved in the process. In addition, endocannabinoid system can also promote exercise participation by regulating the function of the reward system, and form a virtuous cycle with the process of exercise promoting brain health. This paper systematically discusses the structure and biological function of endocannabinoid system, the interaction between exercise and endocannabinoid system, the role of endocannabinoid system in the prevention and treatment of central nervous system dysfunction and obesity through exercise, so as to provide a new perspective and research approach for the theory of promoting brain health through exercise.
Communication Author：CHEN Wei , Email:firstname.lastname@example.org