付岩松1,2 , 郭志涛1,2 , 陈 晨1,2 , 孟祥宁1,2 , 朱 静1,2,*
1哈尔滨医科大学医学遗传学研究室,哈尔滨 150081 2中国遗传资源保护与 疾病防控教育部重点实验室(哈尔滨医科大学),哈尔滨 150081

摘 要:

微小RNA (microRNA, miRNA) 是一类由19~24 个核苷酸构成的内源性的非编码单链RNA,通过与靶基因完全或不完全结合降解mRNA 或抑制mRNA 的翻译,在体内起到转录后调控作用,参与多种生理和病理过程。新近报道发现,miR-338-5P 在黑色素瘤、消化系统肿瘤、肺癌等各种类型的癌症中异常表达,其通过结合一系列的靶基因来调控细胞增殖、转移、侵袭和凋亡,在不同肿瘤中发挥抑癌或促癌的不同作用,并可能成为癌症诊断的生物标志物和治疗靶点。在其他炎性相关疾病中,比如病理性心肌肥厚、类风湿性关节炎等,也发现miR-338-5P 可以通过靶向不同基因,参与疾病的发生发展。现综述miR-338-5P 在肿瘤、肿瘤放化疗以及其他炎性相关疾病中的作用和其在疾病诊断、预后判断等方面的应用,为肿瘤等疾病相关标志物以及更有效的治疗靶点的开发提供新思路。

通讯作者:朱 静 , Email:zhuj@hrbmu.edu.cn

Roles and application potentials of miR-338-5P in human cancers and other diseases
FU Yan-Song1,2 , GUO Zhi-Tao1,2 , CHEN Chen1,2 , MENG Xiang-Ning1,2 , ZHU Jing1,2,*
1Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China 2Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China (Harbin Medical University), Ministry of Education, Harbin 150081, China


MicroRNA (miRNA) is a class of endogenous non-coding single-stranded RNA composed of 19-24 nucleotides. By completely or partially binding to target mRNAs to degrade mRNA or inhibit protein expression, miRNA plays a role in post-transcriptional expression regulation in vivo and is involved in various physiological and pathological processes. New reports found that miR-338-5P is abnormally expressed in melanoma, digestive system tumors, lung cancer and other types of cancers, playing diverse roles through the binding to a series of target genes to regulate cell proliferation, metastasis, invasion and apoptosis in the different background as a tumor suppressor or promoter, and may become cancer biomarkers and therapeutic targets. In other inflammatory diseases, such as pathological cardiac hypertrophy and rheumatoid arthritis, miR-338-5P has also been found to be involved in the occurrence and development of diseases by targeting different genes. The function and application potentials of miR-338-5P in human diseases, including tumors and other inflammatory diseases, were reviewed to provide new ideas for the development of disease diagnosis, prognostic biomarkers and more effective therapeutic targets.

Communication Author:ZHU Jing , Email:zhuj@hrbmu.edu.cn

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