张璐纯 , 袁 梦 , 曹芊梓 , 黄星卫 , 雷 蕾*
哈尔滨医科大学组织学与胚胎学教研室,哈尔滨 150081

摘 要:

N6- 甲基腺嘌呤 (m6A) 作为真核生物RNA 上的一种重要的表观遗传修饰,拥有众多的识别蛋白,形成了复杂多样的调控网络,在调控生物体的生长发育以及疾病的发生中有着重要的作用。该文对m6A 以及其检测方法和阅读蛋白进行简要介绍,着重讨论了m6A 在干细胞干性维持以及胚胎发育中的生物学功能,总结了m6A 与其他分子修饰的联系,讨论了rRNA 上的m6A 修饰,最后对m6A 可能参与的其他生物学过程进行了展望。

通讯作者:雷 蕾 , Email:lei086@ems.hrbmu.edu.cn

Research progress on the regulatory mechanism of m6A modification and its functions in development and stem cells
ZHANG Lu-Chun , YUAN Meng , CAO Qian-Zi , HUANG Xing-Wei , LEI Lei*
Department of Histology and Embryology, Harbin Medical University, Harbin 150081, China


N6-methyladenosine (m6A) is one of the most important epigenetic modifications on eukaryotic RNAs. It is identified by many proteins and forms a complex network, which plays crucial roles in regulating development and diseases. In this review, we briefly introduced the concept of m6A and its readers, as well as its detection methods. Furthermore, we emphasized on the m6A’s biological functions in stemness maintenance and embryo development, summarized the connections between m6A and other modifications, then discussed the effect of m6A in rRNA. In the end, we prospected other processes that m6A may participate in.

Communication Author:LEI Lei , Email:lei086@ems.hrbmu.edu.cn

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