《生命科学》 2021, 33(7): 853-860
通讯作者：张玲莉 , Email:email@example.com
Exosomes are one of the three most widely studied subpopulations of extracellular secretory vesicles, and play a crucial role in mediating intercellular information exchange, and their trans-organ regulation and long-range regulation are one of the reasons why exosome-related tudies have attracted much attention. In recent years, studies related to the regulation of bone homeostasis by exosomes and the mediation of bone metastasis by tumor cells have gradually increased. Although there are more studies on the regulation of skeletal cells by exosomes of extracellular origin, the network of their regulatory activities is still unclear. In this article, we summarize the regulatory effects of extraosseous exosomes on bone, and sort out the regulatory activity network of exosomes secreted by extraosseous organs and tissues, so as to provide a theoretical basis for improving bone microenvironment and resisting bone metastasis of tumor cells by different sources of exosomes.
Communication Author：ZHANG Ling-Li , Email:firstname.lastname@example.org