《生命科学》 2021, 33(7): 810-816
内质网应激是细胞应对蛋白质突变和表达水平异常的防御性反应，包括未折叠蛋白反应(UPR)、内质网相关蛋白质降解(ERAD) 和自噬体形成等多个组成部分。许多研究指出，肿瘤细胞依赖高水平的内质网应激反应以维持生存和高速生长，干扰UPR 和ERAD 可抑制肿瘤细胞的生长。同时，癌细胞发生抗
药的关键机制是产生新的突变，这些突变可能会进一步诱导UPR 和ERAD 等，使抗药癌细胞对内质网应激的抑制剂更加敏感。因此，面对后基因组时代发现的肿瘤细胞突变的多样性、异质性和持续性，靶向细胞对突变的反应——内质网应激，是值得关注和研究的新抗肿瘤策略。
通讯作者：杨义力 , Email:email@example.com
Endoplasmic reticulum stress is a cellular defense response to mutated or inadequately expressed proteins. It is composed of multiple components, including unfolded protein response (UPR), endoplasmic reticulum-associated degradation (ERAD), and autophagy formation. It has been revealed that tumor cells rely on high level of ER stress response to survive and grow rapidly. It has also been shown that meddling UPR and ERAD often induces inhibition of tumor cell growth. Of note, novel mutations are largely responsible for tumor cells to become resistant to chemotherapeutics. It is conceivable that these mutations are able to further augment ER stress response and make the cells more susceptible to inhibition of ER stress response. With the increasing understanding of cancer mutations, their diversity, heterogeneity, and continuity, we believe that targeting the cellular response to mutations represents a novel anti-tumor strategy that is worthy of being further studied and explored.
Communication Author：YANG Yi-Li , Email:firstname.lastname@example.org