《生命科学》 2021, 33(4): 527-533
通讯作者：陈怀永 , Email:email@example.com
The global mortality rate of respiratory diseases remains high. Among them, refractory diseases such as lung cancer, asthma, idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease are all closely related to the altered regulation and functional abnormalities of lung stem/progenitor cells. Lung stem/progenitor cells are region-specific and exhibit the ability to self-renew, proliferate and differentiate, contributing to the repair of epithelium after lung injury. Therefore, lung stem/progenitor cells have attracted more and more attention. Previous studies have shown that the fate and the function of lung stem/progenitor cells are regulated by metabolic pathways including glycolysis, lipid synthesis, pentose phosphate pathway, amino acid metabolism, oxidative phosphorylation and other major metabolic pathways. In addition, there are many links between metabolic pathways and functions of lung stem/progenitor cells. Metabolic alteration in lung stem/progenitor cells may be related to lung aging and diseases. This article reviews the metabolic regulation of lung stem/progenitor cells under normal, aging and disease states.
Communication Author：CHEN Huai-Yong , Email:firstname.lastname@example.org