蔡兆奎 , 薛愿超*
中国科学院生物物理研究所核酸生物学重点实验室,北京 100101

摘 要:



通讯作者:薛愿超 , Email:ycxue@ibp.ac.cn

Research progresses of RNA structure probing technologies
CAI Zhao-Kui , XUE Yuan-Chao*
Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China


RNA molecules usually form intricate secondary and tertiary structures during genetic information transfer to achieve their regulatory and catalytic functions. The dynamic change of RNA structures is an ingenious means for living organisms to adjust gene expression in response to environmental cues quickly. RNA structural
dynamics have been demonstrated to be playing crucial roles in normal physiological processes and pathogenesis. Analyzing the higher-order structure of RNA is the only way to understand the functional mechanism of noncoding RNA in cells. It has received widespread attention and interest and has gradually become a research frontier in the RNA field. This article mainly introduces the progress of diverse RNA structure probing methods, including bioinformatics prediction, low-throughput physical approaches, and emerging high-throughput sequencing
technologies. We also summarize the application and limitations of these research methods.


Communication Author:XUE Yuan-Chao , Email:ycxue@ibp.ac.cn

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