《生命科学》 2021, 33(2): 238-247
通讯作者：李墨林 , Email:email@example.com
miR-221 and miR-222 (miR-221/222) are paralogues arisen from the duplication of the ancestral gene.They are highly homologous miRNAs with identical seed sequence “AGCUACAU”. miR-221/222 are highly expressed in normal endothelial cells and play important roles in vascular biology. Their abnormal expression is closely related to the occurrence and development of cardiovascular, metabolic, immune or neurodegenerative diseases. Recent studies have shown that miR-221/222 were dysregulated in a variety of malignant tumors and were involved in the proliferation, differentiation, apoptosis, invasion and metastasis of tumor cells, indicating that they might be not only bio-markers for diagnosis and prognosis of cancers, but also promising targets for malignant tumor treatment. The progress of miR-221/222 and their target genes in malignant tumors were reviewed in this paper.
Communication Author：LI Mo-Lin , Email:firstname.lastname@example.org