《生命科学》 2021, 33(2): 148-153
通讯作者：张 博 , Email:email@example.com
The African clawed frog (Xenopus laevis) is an important animal model widely used in basic research. It is mainly developed to study the early development of various vertebrate tissues and organs. Compared with other animal models, it is related to kidney development and polycystic kidney disease. The advantages are very obvious in disease exploration. The Xenopus laevis kidney is simple but evolutionarily conservative, and the experimental technology is simple but the results are reliable. It is the key for the study of complex gene regulatory networks in kidney development and disease development. Although the metanephrosis of mice and rats is currently used, the characteristics of the Xenopus laevis itself are indispensable for the study of multiple kidney diseases. This article focuses on the characteristics of the kidney development of the Xenopus laevis and its advantages as a model animal to study polycystic kidney disease. The shortcomings are also reviewed.
Communication Author：ZHANG Bo , Email:firstname.lastname@example.org