摘 要：摘 要：AMP激活的蛋白激酶(AMP-activated protein kinase, AMPK)广泛存在于真核细胞中，一旦被激活，即可磷酸化下游靶蛋白，关闭消耗ATP的合成代谢途径，开启产生ATP的分解代谢途径，被称为“细胞能量调节器”。许多新的下游靶蛋白的发现也为AMPK生物学效应的阐明提供了新思路。
Abstract: Abstract: The AMP-activated protein kinase is found in all eukaryotic cells. Once activated, the kinase switches on ATP-producing catabolic pathways and switches off ATP-consuming processes,both via direct phosphorylation of downstream targets, and thus is called a “cellular energy regulator”. A variety of novel downstream target proteins have been discovered recently, which provide new insight into elucidating precise functions of AMP-activated protein kinase.
Key words: AMP-activated protein kinase; energy metabolism; adenosine monophosphate