摘 要：摘 要：蛋白酪氨酸磷酸酯酶1B (protein tyrosine phosphatase 1B, PTP1B)是典型的非受体型PTPase家族的成员之一。PTP1B在胰岛素信号通路中起着重要的负调控作用，是治疗糖尿病和肥胖症的新靶点。寻找PTP1B的特异性抑制剂，通过抑制PTP1B的活性来提高胰岛素信号通路的敏感性，对糖尿病和肥胖症治疗有着重要的应用前景。
Abstract: Abstract: Protein tyrosine phosphatase 1 B (PTP1B) is a typical member of non-receptor PTP family. PTP1B plays an important role in the negative regulation of insulin signaling pathway. It has been proved to be a novel target for diabetes and obesity. Inhibition of PTP1B抯 activity could improve the sensitivity of insulin signaling. The discovery of highly effective inhibitors of PTP1B has a promising application in diabetes and obesity therapy.
Key words: PTP1B; insulin signaling pathway; negative regulation; diabetes and obesity; inhibitors of PTP1B