中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(1): 84-88
HIV-1 Tat蛋白神经毒作用的研究进展
滕竞飞1,高霄飞2*
(1第二军医大学临床医学八年制,上海 200433;2第二军医大学神经生物学教研室,上海 200433)
摘 要:HIV-1感染者常并发神经系统损伤,患者主要表现为运动功能障碍,认知和行为受损等。研究表明,HIV-1多种蛋白参与上述病理过程,其中Tat蛋白发挥了极为重要的作用。外周Tat蛋白可透过血脑屏障进入脑组织,与脑内感染细胞分泌或释放至胞外的Tat共同作用于NMDAR、mGluR1、多巴胺转运蛋白等,损伤神经系统。该文主要对Tat蛋白的神经毒作用作一综述。
关键词:HIV-1 Tat;血脑屏障;神经毒
 
Progress in study on neurotoxicity of HIV-1 Tat
TENG Jing-fei1, GAO Xiao-fei2*
(1 Eight-year-system Clinical Medicine, Second Military Medical University, Shanghai 200433, China;2 Department of Neurobiology, Second Military Medical University, Shanghai 200433, China)
Abstract: Infection with HIV-1 is always associated with dysfunctions of central nervous system(CNS), the patients are characterized by motor dysfunctions, impaired cognitions and behaviors. Relative researches indicated that, various HIV-1 proteins are responsible for the pathogenesis, among which, Tat is of vital importance. Peripheral Tat, which can cross the blood-brain barrier and infiltrate the brain tissues, as well as that secreted or released from HIV-1-infected cells, can interact with NMDAR, mGluR1, dopamine transporter, etc. and thus cause damages to central nervous system (CNS). The neurotoxicity effects of HIV-1 Tat were reviewed here.
Key words: HIV-1 Tat; blood-brain barrier; neurotoxicity
 
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