中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2010, 22(1): 69-73
HER-2/neu基因高表达及靶向治疗
陈宇萍
(海军总医院基础医学研究中心,北京100048)
摘 要:HER-2/neu癌基因在许多肿瘤,如乳腺癌、卵巢癌、非小细胞肺癌等肿瘤中高表达,在肿瘤的发生与发展中起重要作用,与肿瘤的转化、转移、复发、预后差、患者生存期缩短有关。HER-2/neu在乳腺癌过度表达率约为20%~30%,编码蛋白P185HER2属生长因子受体家族,抗P185HER2单克隆抗体(Herceptin)作为靶向药物已临床应用治疗HER2/neu高表达乳腺癌。
关键词:HER-2/neu基因;P185HER2; 靶向治疗
 
Over-expression of HER-2/neu and targeted therapy
CHEN Yu-ping
(Center of Basic Medical Science, Navy General Hospital of PLA, Beijing 100048, China)
Abstract: HER-2/neu oncogene is overexpressed in many kinds of tumors like breast cancer, ovarian cancer, nonsmall-cell lung cancer(NSCLC). Overexpression of HER-2/neu has significant effect on tumor occuring and development, it is associated with tumor inversion, metastasis, recuring, poorer prognosis and patient{$39}s shortening of life. HER-2/neu is overexpressed in approximately 20%~30% patients with breast cancer. The coding protein P185HER2 of HER-2/neu is a member of the human epidermal growth factor receptor family. Monoclonal antibody of P185HER2(Herceptin) is clinically used as a targeted drug for HER-2/neu overexpressed breast cancer.
Key words: HER-2/neu; P185HER2; targeted therapy
 
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