中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2009, 21(4): 513-516
白细胞介素21的生物学功能及其抗肿瘤效应
李 栋1,俞慧清2,3,魏小元1,成国祥1,2,3*
1同济大学生命科学与技术学院,上海 200092; 2上海交通大学医学院附属瑞金医院,上海 200025; 3上海转基因研究中心,上海 201210
摘 要:白细胞介素21(IL-21)属于I类细胞因子,主要由活化的CD4+ T产生,作用于免疫系统中的大部分骨髓、淋巴细胞,具有广泛的生物学功能,是联系主动免疫与被动免疫的中间因子。IL-21能够调节体液和细胞介导的免疫应答,促进T细胞增殖分化,调节B细胞的增殖分化与调亡,增强NK细胞的细胞毒性作用与免疫监督功能。此外,IL-21还具有抗肿瘤作用,与其他细胞因子、疫苗等联合应用,可增强其抑制肿瘤细胞生长的功能。该文综述了IL-21的生物功能及其应用于抗肿瘤治疗的研究前景。
关键词:白细胞介素21;细胞因子;免疫调节;抗肿瘤作用
 
The biological function and antitumour effect of interleukin-21
LI Dong1, YU Hui-qing2,3, WEI Xiao-yuan1, CHENG Guo-xiang1,2,3*
1School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; 2 Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; 3 Shanghai Transgenic Research Center, Shanghai 201210, China
Abstract: Interleukin-21(IL-21) is a type I cytokine and mainly produced by activated CD4+ T cells. IL-21 targets a broad range of lymphoid and myeloid cells of the immune system and therefore is able to regulate innate and acquired immune responses. IL-21 has effect on T-cell activation, B-cell Ig-production, NK-cell activation. Moreover, Many researchs demonstrated that IL-21 has antitumour activity in several preclinical models. When combining IL-21 with other cytokines or drugs, the antitumour activity can be enhanced. Here, we provide an overview about the biological function of IL-21 and its prospect in cancer therapy.
Key words: IL-21; cytokine; immunoregulation; antitumour
 
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