中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2009, 21(4): 508-512
治疗阿尔茨海默病的早老素/g-分泌酶抑制剂和调节剂
陈天睿,黄雪媚,崔理立,张应玖*
吉林大学分子酶学工程教育部重点实验室,长春 130021
摘 要:阿尔茨海默病(Alzheimer抯 disease,AD) 又称老年痴呆症,是一种中枢神经系统(central nervous system, CNS)退行性疾病。b-淀粉样蛋白(b-amyloid,Ab42)被认为在阿尔茨海默病(AD)的发生、发展过程中起核心作用。Ab42由APP经b-和g-分泌酶相继切割产生。g-分泌酶是一个蛋白酶复合体,早老素(presenilin,PS) 是g-分泌酶的催化组分。因此,抑制PS/g分泌酶的活性是治疗AD的关键,因而PS/g分泌酶也是治疗AD的主要靶点。根据这些理论,人们提出了一些治疗AD的新方法,其中PS/g-分泌酶抑制剂和调节剂成为近年来人们关注的焦点。
关键词:阿尔茨海默病;早老素;g-分泌酶;抑制剂;调节剂
 
Inhibitor and regulator of presenilin for Alzheimer’s disease
CHEN Tian-rui, HUANG Xue-mei, CUI Li-li, ZHANG Ying-jiu*
Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, Jilin University, Changchun 130021, China
Abstract: Alzheimer{$39}s disease is a central nervous system (CNS) degenerative diseases. Amyloid b-peptide(Ab42) is strongly responsible for the occurrence and development of Alzheimer{$39}s disease(AD). Ab42 peptide is resulted from the sequential proteoiytic cleavages of amyloid precursor protein (APP) by b- and g-secretases. g-secretase is a protease complex, and presenilin (PS) is the catalytic component of g-secretase complex. Therefore, inhibition of PS or g-secretase activity is the most effective way to treat AD, accordingly, PS or g-secretase became a major target for AD treatment. Based on these thoughts, some methods of treating AD are put forward, and the inhibitors and regulators of PS or g-secretase activity are becoming the focus of attention for the treatment of Alzheimer{$39}s disease in recent years.
Key words:Alzheimer{$39}s disease; presenilin; g-secretase; inhibitor; regulator
 
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