中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2009, 21(4): 560-565
Let-7家族对细胞“干性”的调控
王斯瑶1,安 靓2*
1 南方医科大学基础医学院基础医学系,广州 510515;2 南方医科大学肿瘤研究所,广州 510515
摘 要:Let-7是目前研究最为广泛的microRNA家族之一。通过转录后调控机制,let-7可以特异性结合到信使RNA(mRNA)上,从而降解靶基因mRNA或抑制其翻译。研究表明,let-7家族在干细胞与肿瘤干细胞中参与多种调控机制,在维持干细胞特性(stemness),即高增殖、低分化和自我更新能力的过程中起到重要调控作用。本文将从干细胞与肿瘤干细胞两个方面,综述let-7与细胞“干性”间存在的联系和调控机制。
关键词:let-7;microRNA;干细胞;肿瘤干细胞
 
Regulating function of let-7 family on cell stemness
WANG Si-yao1, AN Jing2*
1 Basic Medicine, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China; 2 Cancer Institute of Southern Medical University, Guangzhou 510515, China
Abstract: Originally discovery indicates a class of miRNA, let-7, which binds to target messenger RNAs (mRNA) through a post-transcription regulation and induces either translation repression or mRNA degradation, plays a regulatory role in the stem cells /cancer stem cells self renewal, development, differentiation, metastasis and apoptosis. Based on these findings about let-7抯 function and its regulatory processes, this review will summarizes these processes and the potential role in the stem cell and cancer stem cell. A more complete understand of its function on stemness will thus find new solution to the research, the diagnose and therapy of human cancer.
Key words: let-7; microRNA; stem cell; cancer stem cells 
 
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