中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2009, 21(2): 259-263
大气可吸入颗粒物造成肺损伤的NF-kB研究进展
彭 辉,周绮云,刘 璇,赵晓红*
北京联合大学应用文理学院,北京 100083
摘 要:NF-kB信号通路在大气可吸入颗粒物(PM10)对肺的损伤过程中起到重要的作用,但NF-kB信号通路参与的损伤机理尚不清楚。本文对NF-kB的结构与组成、颗粒物中NF-kB的激活因素、激活过程和抑制剂的相关研究等内容做简要综述。
关键词:大气可吸入颗粒物;NF-kB信号通路;NF-kB通路抑制剂
 
Progress of study on the NF-kB signaling pathway in the lung injury induced by inhalable particle
PENG Hui, ZHOU Qi-yun, LIU Xuan, ZHAO Xiao-hong*
College of Applied Arts and Sciences, Beijing Union University, Beijing100083, China
Abstract: Many epidemiologic studies have shown that the NF-kB signaling pathway plays an important role in the lung injury by induction of inhaled particle matter. However, the exact toxicological damage mechanisms which the NF-kB signaling pathway takes part in are still unresolved. This paper described the progress of study on the NF-kB signaling pathway in the lung injury induced by inhaled particle matter home and abroad. In this article, the component of NF-kB, the activate factor of NF-kB in particle matter, the activation process and the inhibitor were reviewed.
Key words: inhalable particle; NF-kB signaling pathway; NF-kB signaling pathway inhibitor
 
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