中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2009, 21(1): 72-75
Z-DNA及其生物学功能
汤雅男,杨 攀,胡成钰*
南昌大学生命科学学院,南昌 330031
摘 要:Z-DNA是一种处于高能状态、不稳定的DNA分子构象。形成Z-DNA的原因有很多:首先,转录过程中,移动的RNA聚合酶在模板DNA的5{$39}端产生负超螺旋扭曲力,导致Z-DNA的形成;其次,含有d(GC)n序列的核酸分子在高浓度的NaCl、[Co(NH3)6]2+盐溶液中也能够形成Z-DNA;最后,化学修饰也可以使DNA产生稳定的Z-DNA。Z-DNA是在体外首先发现的,但随着研究的不断深入,发现Z-DNA在体内也广泛存在并可能具有功能的多样性,包括参与基因表达调控、染色体断裂、基因重组、抗病毒、病毒发生等生物学过程。
关键词:Z-DNA;基因表达;Z-DNA结合蛋白;干扰素系统
 
Z-DNA and its biological function
TANG Ya-nan, YANG Pan, HU Cheng-yu *
College of Life Science, Nanchang University, Nanchang 330031, China
Abstract: Z-DNA is an instable and high energy DNA conformation in vivo and it can be formed in many conditions. Firstly, when RNA polymerase is moving on a DNA template, transcription can result in negative supercoiling behind the polymerase, thus facilitating Z-DNA conformation at permissive regions. Secondly, the Z-DNA-conformation which is formed by d(GC)n sequence can also be stabled in high-salt solution of NaCl or [Co(NH3)6]2+ and lastly, the Z-DNA can be formed by covalent modifications. Though Z-DNA was firstly discovered in vitro, recently many evidences revealed that Z-DNA was widely existed and may possessed diversity of function in vivo, including gene expression and regulation, chromosomal breaks, recombination, antivirus defense and virus generation and so on.
Key words: Z-DNA; gene expression; Z-DNA binding protein; IFN system
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2955112 位访问者,欢迎!