中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(6): 843-
人乳头瘤病毒及其致瘤机制的研究进展
梁德光, 何之恒, 蓝 柯*
中国科学院上海巴斯德研究所,上海200025
摘 要:高危型人乳头瘤病毒(human papilloma virus, HPV)的持续感染是导致妇女宫颈癌发生的一个关键因素。HPV感染宫颈上皮细胞后,可以通过抑制免疫应答,在部分个体中建立潜伏感染。高危HPV编码的蛋白在持续感染的过程中,操控了细胞多种重要功能,如凋亡、增殖、细胞周期调控等,使得宫颈上皮细胞的形态学、遗传物质、表观遗传学等都发生重要改变。部分感染人群的宫颈上皮细胞因此会被转化,并在协同因子相互作用下,逐渐转化为宫颈癌。HPV在宫颈癌发生过程中起着重要的作用,本文将对HPV感染致宫颈癌机制最近的研究进展进行综述。
关键词:人乳头瘤病毒;致瘤;宫颈癌
 
Reseach progress on human papilloma virus and its related carcinogenesis
LIANG De-guang, He Zhi-heng , LAN Ke*
Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200025, China
Abstract: Persistant infection of high risk HPV (human papilloma virus) is a critical factor to the onset of women cervical carcinoma. HPV can infect cervical epithelium and establish latent infection through down-regulation of host immune response. Viral proteins encoded by high risk HPV modulate multiple cellular functions during persistant infection, such as apoptosis, proliferation and cell cycle regulation. As a result, the morphology, genetic materials, and epigenetics of cervical epithelium can be changed dramatically. In some cases, HPV infected epithelium can be transformed and further developed to cervial cancer with the assistance of some co-factors. In a word, HPV plays an important role in cervical oncogenesis. This review will introduce recent research progress on the mechanisms by which HPV induces cervical cancer.
Key words: human papilloma virus; carcinogenesis; cervical carcinoma
 
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