中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(5): 807-
F-box蛋白家族及其功能
王秀燕1,孙莉萍1*,张建锋1,李 辉1,吕文清3,张其清1,2*
(1厦门大学生物医学工程研究中心,福建省生物医学工程重点实验室,厦门 361005;2中国医学科学院,中国协和医科大学生物医学工程研究所,天津市生物医学材料重点实验室,天津 300192;3厦门大学抗癌研究中心,厦门 361005)
摘 要:F-box蛋白是一类广泛存在于真核生物中,含有F-box结构域的蛋白家族,在泛素-蛋白酶体途径(ubiquitin-proteasome pathway, UPP)中因特异识别底物蛋白而参与细胞周期调控、转录调控、细胞凋亡、细胞信号转导等生命活动。另外,F-box蛋白还通过其他作用方式参与了体内众多生化过程。本文综述了F-box蛋白的结构和作用途径,以及该蛋白参与的多种生理功能,展示了F-box蛋白家族在生命活动中具有广泛而重要的作用,并指出了F-box蛋白将为阐明疾病发生机制提供新的线索,可望成为疾病治疗中药物作用的靶向位点。
关键词:F-box蛋白;泛素-蛋白酶体途径;SCF复合体
中图分类号:Q51  文献标识码:A
 
F-box proteins and their functions
WANG Xiu-yan1, SUN Li-ping1*, ZHANG Jian-feng1, LI Hui1, L?Wen-qing3, ZHANG Qi-qing1,2*
(1 Research Center of Biomedical Engineering, Xiamen University, Key Laboratory of Biomedical Engineering of Fujian, Xiamen 361005, China; 2 Institute of Biomedical Engineering, Chinese Academy of Medical Science &Peking Union Medical College, Key La
Abstract: F-box proteins are an expanding family of eukaryotic proteins characterized by an 揊-box?motif. They are in charge of substrate specificity in the ubiquitin-proteasome pathway and therefore play a pivotal role in many physiological activities such as cell-cycle progression, transcriptional regulation, programmed cell death and cell signal transduction. In addition, F-box proteins participate in many other biochemical processes through different ways. In this review we focus on the structure and function of F-box proteins and reveal that this protein family has an important role in life. Furthermore, we indicate that F-box proteins are attractive candidates in the disease therapy and drug interaction.
Key words: F-box protein; function; ubiquitin proteasome pathway; SCF complex
 
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