中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(5): 790-
蛋白质相互作用调控蛋白质核转运及其功能
陈 斯,王 建,杨晓明*
(军事医学科学院放射与辐射医学研究所,北京 100850)
摘 要:蛋白质的核转运是真核生物细胞内发生的重要过程之一,是一大群蛋白质发挥其功能的前提,与细胞正常功能的维持密切相关。蛋白质的核运输通常采用核受体介导的方式进行。此过程非常复杂,需要多种蛋白质的参与,涉及到大量的蛋白质相互作用。本文将综合近年来本领域取得的进展,就蛋白质相互作用参与蛋白质核转运来调节蛋白质的亚细胞定位,进一步在多方面影响细胞以及生物体生理功能的变化进行阐述。
关键词:蛋白质;核转运;相互作用
中图分类号:Q51;Q816  文献标识码:A
 
Protein-protein interaction is essential on nuclear transport and function of nuclear located proteins
CHEN Si, WANG Jian, YANG Xiao-ming*
(Beijing Institute of Radiation Medicine, Beijing 100850, China)
Abstract: Nuclear transport is an important event in eukaryotic cells, which is the key prerequisite for functional proteins and cell viability. Nuclear transport of proteins is always mediated by nuclear import receptors, which is a very complicated process and involves lots of different proteins and protein-protein interactions. This article reviews recent progress in this field within last a few years. We talk about protein sub-cellular translocation regulated by protein-protein interaction involved in nuclear transport, and discuss its impact on cellular physiological functions in distinct aspects.
Key words: protein; nuclear import; interaction
 
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