中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(4): 638-
病毒利用UPP逃避抗病毒反应的研究进展
赵 朴,贾贝贝,王宪文,刘兴友,郑玉姝*
(河南科技学院动物科学学院,新乡453003)
摘 要:泛素-蛋白酶体途径是溶酶体外蛋白降解的主要系统,在许多细胞功能中发挥重要作用。越来越多的证据表明病毒参与泛素-蛋白酶体途径,干扰IFN信号通路和免疫受体表达、凋亡抑制及介导病毒潜伏。深入理解病毒利用泛素-蛋白酶体途径逃避宿主抗病毒反应的策略,有助于揭示病毒的致病机理和鉴定抗病毒药物新靶标。
关键词:病毒;泛素-蛋白酶体途径;逃避;抗病毒反应
中图分类号:Q939.91  文献标识码:A
 
Research progress in the UPP used by viruses to escape antivirus response
ZHAO Pu , JIA Bei-bei , WANG Xian-wen, LIU Xing-you , ZHENG Yu-shu*
(Department of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang 453003, China)
Abstract: The ubiquitin-proteasome pathway (UPP), a major intracellular system for extralysosomal protein degradation, plays an important role in a wide variety of cellular functions.More and more evidences indicate that viruses are involved in the UPP for interfering with IFN signalling pathways and expression of  immunoreceptors, apoptosis suppression and mediating viral latency. A better understanding of the strategies used by viruses for evading antivirus response offers an immense opportunity not only to reveal the mechanism of viral pathogenesis, but also to identify novel molecular targets for developing antiviral reagents.Therefore, the latest progress in the UPP used by viruses to escape antivirus response are reviewed in the paper.
Key words: virus; UPP ; escaping ; antivirus response
 
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