中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(4): 633-
细菌作为抗肿瘤剂的研究进展
强火亮1,陈代杰3*,戈 梅2,罗敏玉2
(1上海师范大学生命与环境科学学院,上海 200234;2上海来益生物药物研究开发中心,上海 201203;3上海医药工业研究院,上海 200040 )
摘 要:厌氧和兼性厌氧细菌能够专一性地优先累积在肿瘤的低氧量和坏死的区域,这使其具有很好的靶向性。它们能够分泌毒素或水解酶以及引起针对肿瘤的免疫反应,具有溶瘤作用。基因工程技术能够改造这些细菌使其具有抗肿瘤的特性,进一步增加治疗效果。最新的研究发现,这些细菌的某些代谢产物也具有增强肿瘤治疗效果的作用,为肿瘤的治疗提供了新的思路。本文对细菌作为抗肿瘤剂的相关研究进行综述。
关键词:厌氧细菌;兼性厌氧细菌;联合溶菌疗法;脂质体酶
中图分类号:Q939.1;Q730.59  文献标识码:A
 
Progress of bacteria as anti-tumor agents
QIANG Huo-liang1, CHEN Dai-jie3*, GE Mei2, LUO Min-yu2
(1Life and Environment Science College, Shanghai Normal University, Shanghai 200234, China; 2Health Creation Center for Biopharmaceutical R&D, Shanghai 201203, China; 3Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China)
Abstract: The obligate anaerobes and facultative anaerobes tend to be accumulated specifically in the hypoxic and necrotic regions of tumors as these regions provide those bacteria with necessary anaerobic microenvironment for bacterial germination, which would lead to better tumor targeting. These bacteria have oncolytic abilities, because they can secrete toxin or hydrolase resulting in immune response aiming to neoplasm. Genetic engineering technology would endow these bacteria with anti-tumor properties, resulting in more significant and prolonged anti-tumor effects. Recent research indicated that some metabolites from these bacteria can also enhance the efficacy of anticancer, which provide a new idea for the treatment of neoplasm. This article reviews the research progress in anticancer therapy of bacteria.
Key words: obligate anaerobes;facultative anaerobes;combination bacteriolytic therapy (COBALT) ;liposomase
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2953320 位访问者,欢迎!