中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(4): 625-
MUC1与肿瘤转移的研究进展
万紫微, 黄 雷*
(上海交通大学医学院,上海 200025)
摘 要:黏蛋白1(MUC1)是一种高分子量跨膜糖蛋白,广泛分布于机体正常黏膜表面,具有多种功能。MUC1在肿瘤组织中异常表达,与肿瘤的侵袭、转移和预后密切相关,具有重要的临床应用价值。本文对MUC1的结构、功能及其在多种肿瘤转移中的研究进展进行了综述,并对其在肿瘤的临床诊断及治疗中的作用进行了展望。
关键词:MUC1;肿瘤转移;预后
中图分类号:Q513.2;R73-37  文献标识码:A
 
MUC1 in tumor progression and metastasis
WAN Zi-wei, HUANG Lei*
(School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China)
Abstract: MUC1 is a large, heavily glycosylated and transmembrane protein expressed on the surfaces of most simple, secretory epithelia, which has multiple functions. Since it is often overexpressed in many tumors and closely related to invasion, metastasis and prognosis of the malignancy, MUC1 might be exploited as a tumor marker for clinical application. This article reviews the structure and function of MUC1 and some new research progress on the tumor metastasis related to MUC1, and explores its significance in tumor diagnosis and treatment.
Key words: MUC1; tumor metastasis; prognosis
 
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