中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(4): 611-
胞内接头蛋白TRAFs家族
张万巧,王 建*
(北京蛋白质组研究中心,蛋白质组学国家重点实验室,北京放射与辐射医学研究所,北京 102206)
摘 要:肿瘤坏死因子(tumor necrosis factor, TNF)受体相关因子(receptor-associated factor, TRAF)家族是一类胞内接头蛋白,能介导TNF受体和Toll-like/IL-1受体超家族成员与多种下游信号通路包括NF-kB(nuclear factor kB)和JNK(Jun N-terminal kinase)的信号传导。TRAF蛋白家族参与调控细胞增殖、分化乃至凋亡等生理过程。由于其在信号通路中的关键作用,TRAFs蛋白的失调与多种疾病的发生相关。本文结合最新的研究进展对TRAFs蛋白家族在信号传导通路中的地位进行介绍,并探讨了TRAFs及其相关蛋白在临床上可能的应用前景。
关键词:TNF受体超家族;TRAF;接头蛋白
中图分类号:R730.5; Q51  文献标识码:A
 
Intracellular adaptor proteins TRAFs family
Zhang Wan-qiao, Wang Jian*
(State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China)
Abstract: The tumor necrosis factor (TNF) receptor-associated factor (TRAF) family is a group of adapter proteins that couple the TNF and Toll-likel/IL-1 receptor family to diverse kinase cascades which ultimately lead to the activation of NF-kB (nuclear factor kB), JNK (Jun N-terminal kinase) and other signaling pathways. TRAFs can join in the regulation of cellular processes ranging from cell proliferation and differentiation to apoptosis. The pleiotropic effects of TRAFs allows the involvement of different TRAF family members in the etiology of a variety of pathologies. We introduce the key role of TRAFs in signal pathways with new research results and discuss the possibility of regarding TRAF-family proteins and the partner proteins as therapeutic approaches in clinic.
Key words: TNF receptor superfamily; TRAF; adaptor protein
 
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