中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(4): 566-
线粒体呼吸链膜蛋白复合体的结构
孙 飞1*,周强军1,孙 吉1,翟宇佳1,饶子和2
(1中国科学院生物物理研究所生物大分子国家重点实验室,北京 100101;2清华大学“清华-南开-生物物理所”结构生物联合实验室,北京 100086)
摘 要:线粒体作为真核细胞的重要“能量工厂”,是细胞进行呼吸作用的场所,呼吸作用包括柠檬酸循环和氧化磷酸化两个过程,其中氧化磷酸化过程的电子传递链(又称线粒体呼吸链)位于线粒体内膜上,由四个相对分子质量很大的跨膜蛋白复合体(I、II、III、和IV)、介于I/II 与III之间的泛醌以及介于III 与IV之间的细胞色素c共同组成。线粒体呼吸链的功能是进行生物氧化,并与称之为复合物V的ATP合成酶(磷酸化过程)相偶联,共同完成氧化磷酸化过程,并生产能量分子ATP。线粒体呼吸链的结构生物学研究对于彻底了解电子传递和能量转化的机理是至关重要的,本文分别论述线粒体呼吸链复合体I、II、III和IV的结构,并跟踪线粒体呼吸链超复合体的结构研究进展。
关键词:线粒体呼吸链膜蛋白复合体;结构生物学;NADH泛醌氧化还原酶;琥珀酸泛醌氧化还原酶;细胞色素c还原酶;细胞色素c氧化酶
中图分类号:Q244;Q518.3  文献标识码:A
 
Structure of mitochondrial respiratory membrane protein complexes
SUN Fei1*, ZHOU Qiang-jun1, SUN Ji1, ZHAI Yu-jia1, RAO Zi-he2
(1 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; 2 Tsinghua-Nankai-IBP Joint Research Group for Structural Biology, Tsinghua University, Beijing 100086, China)
Abstract: As the important “energy factory” of eukaryotic cells, mitochondrion is the place for cellular respiration that includes citric acid cycle and oxidative phosphorylation process (OXPHOS). The OXPHOS electron transfer chain (mitochondrial respiration chain) is located on the inner membrane of mitochondrion and comprising of four large trans-membrane protein complexes (mitochondrial respiratory Complex I, II, III and IV) as well as ubiquinone between Complex I/II and III and cytochrome c between Complex III and IV. The function of mitochondrial respiration chain is biological oxidation which is coupled with phosphorylation by ATP synthesis enzyme (ATPase, called Complex V) and then complete OXPHOS producing energy molecule ATP. Structural researches on those membrane protein complexes in mitochondrial respiration chain are very important for understanding the mechanisms of electron transfer and energy transformation. Here we reviewed the structural studies of mitochondrial respiratory complexes respectively as well as the structural research progresses on their respiratory supra complexes.
Key words: mitochondrial respiratory complexes; structural biology; NADH: ubiquinone oxidoreductase;  succinate:ubiquinone oxidoreductase; cytochrome c reductase; cytochrome c oxidase
 
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