中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
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《生命科学》 2008, 20(4): 560-
简述调控线粒体形态变化的分子机制
王 斌1,2,蒋春笋1,2,3,肖伟明1,2,4,陈 佺1,2*
(1中国科学院动物研究所,生物膜与膜生物工程国家重点实验室,北京 100101;2南开大学生命科学学院,天津 300071; 3江汉大学,武汉 430050;4北京大学生命科学学院,北京 100871)
摘 要:线粒体是细胞内高度动态变化的细胞器,其在细胞内不断运动、融合、分裂并形成动态平衡的网状结构。线粒体的融合和分裂是由多种蛋白精确调控完成。Mfns/Fzo1p控制线粒体外膜的融合,而Mgm1p/OPA1则参与线粒体内膜的融合;Dnm1p/Drp1、Fis1p/Fis1和Mdv1p介导线粒体分裂的调控。线粒体形态对于细胞维持正常生理代谢和机体发育起着重要的作用,一旦调控出现障碍会导致严重的疾病。
关键词:线粒体;融合;分裂;动态变化
中图分类号:Q731  文献标识码:A
 
The molecular mechanism for mitochondria dynamics
WANG Bin1,2, JIANG Chun-sun1,2,3, XIAO Wei-ming1,2,4, CHEN Quan1,2*
( 1 College of Life Sciences, Nankai University, Tianjin 300071, China; 2 The National Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; 3 Jianghan University, Wuhan 4
Abstract: Mitochondria are highly dynamic organelles in a living cell, and display continuous movement, fusion and fission to form mitochondrial reticulum. Mitochondrial fusion and fission are regulated by a number of proteins. Mitochondrial fusion is mediated by the out-membrane protein, fuzzy onions (Fzo1p) in yeast, or its homologues mitofusion 1 (Mfn1) and Mfn2 in mammalian. An intermembrane protein, Mgm1p in yeast and OPA1 in mammalian, are involved in inner membrane fusion. On the other hand, mitochondrial fission is regulated by several proteins called Dnm1p, Fis1p and Mdv1p in yeast and Drp1, Fis1 in mammalian. The normal mitochondrial morphology is important for the function and physiology of mitochondria and cells, and defects in mitochondrial dynamics may cause severe diseases.
Key words: mitochondria; fusion; fission; dynamics
 
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