中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(3): 463-
SDF-1/CXCR4轴在缺氧缺血性脑损伤中的研究进展
李士勇,邓宇斌*
(中山大学中山医学院病理生理教研室,广州 510080)
摘 要:干细胞在许多组织器官显示巨大的细胞分化潜能,其治疗缺血缺氧性疾病成为当前研究的热点。已知局部缺血可诱导干细胞的动员,并能感受组织损伤而定向迁移到损伤区并进行分化。具有趋化因子受体4(CXC chemokine receptor 4,CXCR4)的干细胞迁移到高表达间质细胞来源的因子-1(stromal cell-derived factor-1,SDF-1)的组织区域,这种细胞的迁移运动能被CXCR4拮抗剂所阻断或通过CXCR4的过表达增强迁移的运动。SDF-1-CXCR4轴是体内各种类型的干细胞迁移及细胞在骨髓的滞留和归巢中的重要调节物质。本文就缺氧缺血性脑损伤的骨髓间质干细胞(bone marrow stromal cell,BMSC)治疗, SDF-1-CXCR4轴在MSCs动员和损伤、修复中的作用作一综述。
关键词:基质细胞衍生因子-1; 迁移; 干细胞; 缺血缺氧
中图分类号:Q813; R743.31  文献标识码:A
 
Research progress in effects of SDF-1/CXCR4 axis onhypoxia-ischemia brain injury
LI Shi-yong, DENG Yu-bin*
(Department of Pathophysiology, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510080, China)
Abstract: Stem cells have exhibited great differentiation potentiality, which can be used in therapy for ischemia-hypoxia diseases. Ischemia is known to induce mobilization of stem cells. The tissue injury is {$39}sensed{$39} by the stem cells and they migrate to the site of damage and undergo differentiation. The SDF-1/CXCR4 axis is mediator for the migration of many types of stem cells and stagnation and homing of bone marrow cells. CXCR4 stem cells migrate to the sites highly expressing SDF-1.The cells trafficking can be blocked by CXCR4(CXC chemokine receptor 4)antagonist or enhanced by overexpression of CXCR4. The aim of this review is to summarize recent studies into the role of SDF-1/CXCR4 axis in migration and tissue recovery of bone marrow stromal cells and the BMSCs based therapy for hypoxia-ischemia brain damage.
Key words: stromal cell-derived factor-1; migrate; stem cell; hypoxia-ischemia brain injury
 
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