中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(3): 458-
细胞信号转导与X连锁的非特异性精神发育迟滞
张来军1,2, 贾敬芬1*, 张富昌1*
(1 西北大学生命科学学院,西安 710069;2 甘肃省陇东学院生命科学系,庆阳 745000)
摘 要:非特异性精神发育迟滞是患者仅表现出一般或特殊认知功能障碍的一种病症。对相关的基因及其生理功能进行研究,不仅对弄清非特异性精神发育迟滞的遗传基础有重要意义,还能揭示人类认知功能的分子遗传机理。文章对一些涉及X连锁的非特异精神发育迟滞的基因,其表达产物同时参与细胞信号转导的信号分子,如跨膜受体、鸟苷酸相关蛋白和激酶的生理功能及其研究现状进行了阐述,揭示了细胞信号转导与人类认知活动之间的密切关系,为精神发育迟滞的治疗或预防提供新思路。
关键词:非特异性精神发育迟滞;信号转导;G蛋白
中图分类号:R749.1;Q25  文献标识码:A
 
Signal transduction and X-linked non-specific mental retardation
ZHANG Lai-jun1,2, JIA Jing-fen 1*, ZHANG Fu-chang1*
(1 College of Biological Sciences, Northwest University, Xi抋n 710069, China;2 Department of Life Science, Longdong College, Qingyang 745000, China )
Abstract: Non-specific mental retardation(NSMR) is a kind of disease, of which patients appear simple phenotypes of generic or specific cognitive impairment. Studying of the biological functions of NSMR related genes is of great importance, not only to clarify the genetic basis of NSMR, but also to reveal the molecular genetic mechanisms of human cognitive function. This paper expounds the physiological  functions and recent progresses of X-linked NSMR related genes, and the proteins they coded, such as transmembrane receptors, guanine nucleotide related proteins, and kinases, which play a crucial role in the signal transduction. The closed relation between human cognitive behavior and signal transduction is illustrated, which might provide a new in sight for prevention and therapies of mental retardation.
Key words:  non-specific mental retardation; signal transduction; guanine nucleotide-binding proteins
 
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