中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(3): 442-
组蛋白赖氨酸甲基化修饰与肿瘤
郑 杰
(东南大学基础医学院病理与病理生理学系,南京210009)
摘 要:对组蛋白甲基化修饰认识已有相当长的时间, 但直到最近几年由于组蛋白甲基化修饰酶的发现才使人们逐渐认识到组蛋白甲基化修饰有广泛的生物学功能,像异染色质形成、X染色体失活、转录调节、干细胞的维持和分化等,组蛋白甲基化修饰的改变与某些人类疾病和肿瘤也有一定关系。组蛋白修饰是可逆性的, 这为某些疾病的治疗提供了新的可能。
关键词:组蛋白赖氨酸; 甲基化; 肿瘤
中图分类号:Q344.14; R730.23  文献标识码:A
 
Histone lysine methylation and cancer
ZHENG Jie
(Department of Pathology and Pathophysiology, School of Basic Medical Science, Southeast University, Nanjing 210009, China)
Abstract: It has been known for a considerable time that histone protein can be modified by methylation. However, its functions remained elusive until the histone modifying enzymes were recently identified. With the advances on the biology of histone methylation, it is becoming clear that histone methylation plays widely biological functions such as heterochromatin formation, X inactivation, transcriptional regulation, stem cell maintenance and differentiation. Alterations in histone methylation are associated with human disease and cancer. Owing to the reversible nature of these epigenentic modifications, molecular studies of histone methylation may offer therapeutic possibilities for a wide spectrum of disease.
Key words:  histone lysine; methylation; cancer
 
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