中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(2): 268-
微管解聚相关蛋白质Kinesin-13、Stathmin和Katanin
吴作基,蒋蕾蕾,王春光*
(同济大学蛋白质研究所,上海200092)
摘 要:微管是细胞骨架的主要成份,参与细胞内物质的运输与细胞形态的维持,还与有丝分裂和减数分裂等生命活动密切相关。大多数微管都表现出动力学的不稳定性,处于动态的聚合和解聚及之间的随机转换状态。Kinesin-13、Stathmin和Katanin是三类能够解聚微管的蛋白质,在纺锤体组装、染色体分离和神经元发育过程中起重要作用。本文主要对这三类微管解聚相关蛋白质的结构、功能、解聚机制进行了简要介绍,并对它们的解聚机制进行了比较。
关键词:微管蛋白;Kinesin-13;Stathmin;Katanin
中图分类号:Q245;Q253;Q28  文献标识码:A
 
Microtubule regulatory proteins Kinesin-13, Stathmin and Katanin
WU Zuo-ji, JIANG Lei-lei, WANG Chun-guang*
(Institute of Protein Research, Tongji University, Shanghai 200092, China)
Abstract: Microtubules, an important cytoskeleton, play essential roles in the maintenance of cytomorphology and cellular inner structure, and act as tracks on which motor proteins transport cargoes. Most microtubules exhibit dynamic instability-a behavior where polymerizing and depolymerizing microtubules coexist in the same population, infrequently interconverting between these two states. Kinesin-13, Stathmin and Katanin can depolymerize microtubules and have critical functions in spindle assembly, chromosome segregation and neuronal development. Here, several aspects of kinesin-13, stathmin and katanin are reviewed briefly, including their structures, functions and the mechanisms of microtubule depolymerization. The depolymerizing mechanisms of these three proteins are also compared.
Key words: tubulin; Kinesin-13; Stathmin; Katanin
 
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