中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(2): 241-
皮肤表皮干细胞的研究进展
李丽文, 林凤珠, 许 新, 林钧浩, 张彦定*
(福建师范大学生命科学学院发育与神经生物学重点实验室,福州350108)
摘 要:成体的皮肤一生都在不断的自我更新,其中的毛囊还是保证毛发进行生长-脱落周期循环的细胞组织学基础。存在于表皮内的干细胞维持了成体皮肤的自我平衡及毛发再生。表皮是由构体分子组成。每个构体分子包含毛皮脂单位(毛囊和皮脂腺)及其周围的毛囊间表皮。毛囊间表皮具有祖细胞,损伤时能自我更新;毛囊具有多能干细胞,在新毛发周期开始或者损伤时能够启动干细胞功能,为毛囊的生长或表皮的修复提供细胞来源。本文概述了当前对表皮干细胞的认识,着重阐明毛囊间表皮内有祖细胞的证据,毛囊间表皮干细胞在体外的自我更新能力,毛囊膨突部内干细胞的特征和一些相关基因的表达等。
关键词:表皮干细胞; 毛囊; 多潜能; 自我更新
中图分类号:Q813  文献标识码:A
 
Epidermal stem cells in the skin
LI Li-wen, LIN Feng-zhu, XU Xin, LIN Jun-hao, ZHANG Yan-ding*
(Higher Educational Key Laboratory of Fujian Province for Development and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou 350108, China)
Abstract: Adult抯 skin constantly self-renewes during the life, hair-follicle guarantees the hair carries on the cycle of growth-degeneration.The stem cells existing in the epidermis maintain the adult skin follicle regeneration and skin homeostasis. Adult抯 epidermis is make up of molecular building blocks, each of which consists of interfollicular epidermis, hair-follicle and sebaceous gland. The interfollicular epidermis itself has progenitor cells, which renew when injure occurs, and hair-follicle has the multipotent cells, when the new hair cycle starts or injure occurs which can activate the stem cells, provide cells for the hair-follicle regeneration and the epidermis repair. This article summarized the current understanding of the epidermis stem cells, including the evidence of the interfollicular epidermis containing progenitor cells, and the cells self-renewal in vitro, the characteristic and some gene expression of hair-follicle bulge stem cells.
Key words: epidermal stem cells; hair-follicle; multipotent; self-renewal
 
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