中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(2): 237-
调节表皮干细胞增殖和分化的信号通路
杨蕾蕾,杨 晓*
(军事医学科学院生物工程研究所,北京 100071)
摘 要:表皮干细胞能够维持正常表皮的新陈代谢、毛囊周期循环以及参与创伤情况下创面的修复,皮肤肿瘤的发生也与其密切相关。表皮干细胞的增殖和分化受到严格的调控,了解表皮干细胞增殖与分化的调控机制将有助于治疗脱发、创伤以及皮肤肿瘤等疾病。文章着重概述了Wnt和Bmp信号对于控制干细胞命运的重要作用。
关键词:表皮干细胞;增殖;分化;调控;Wnt;Bmp
中图分类号:Q813  文献标识码:A
 
Signaling pathways that mediate epithelial stem cell proliferation and differentiation
YANG Lei-lei, YANG Xiao*
(Beijing Institute of Biotechnology, Beijing 100071, China)
Abstract: Epithelial stem cell plays pivotal role in maintaining epithelial metabolism, hair follicle cycling, repairing the epidermis on injury, and has close relationship with skin tumorigenesis. Understanding the signaling pathways, which is important for keeping stem cell undifferentiated phenotype, and the mechanism of proliferation and differentiation may help to treat hair loss, wound healing and skin tumors et al. In this paper, we summarize  the effect of Wnt signaling and Bmp signaling on the fate of epithelial stem cell.
Key words: epithelial stem cell; proliferation; differentiation; regulation; Wnt; Bmp
 
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