中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(1): 95-
小胶质细胞与阿尔茨海默病
蔡志友,晏 勇*
(重庆医科大学附属第一医院神经内科 重庆市神经病学重点实验室,重庆400016)
摘 要:国内外对阿尔茨海默病(Alzheimer抯 disease, AD)神经元病理和神经胶质细胞病理机制进行了大量探索,小胶质细胞 (microglia, MG) 是中枢神经系统的免疫细胞,在致炎因素作用下它被激活成反应性MG,反应性MG既具有保护神经元的作用,也能分泌细胞毒因子、补体蛋白而损害神经元。尽管目前AD发病机理还不清楚,但大多数学者认为b淀粉样蛋白(Ab)沉积激活MG引起的炎症反应是AD的核心病理机制。
关键词:阿尔茨海默病;小胶质细胞;老年斑;神经纤维缠结;炎症
中图分类号:R749.1; Q2  文献标识码:A
 
Microglia in Alzheimer’s disease
CAI Zhi-you, YAN Yong*
(The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China)
Abstract : Glial pathogenesis in Alzheimer抯 disease has been researched more. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. Microglia(immunological cell of central nervous system) can prevent neural impairment. Activated microglia is produced by stimulation of proinflammatory factors.  Activated microglia can release cytotoxic factors, complements to injure neuron.Although pathogenesis of Alzheimer抯 disease hasn{$39}t been clear, neuro-inflammation from deposition of b-amyloid has been accepted as a  pathalogical core for Alzheimer{$39}s disease.
Key words: Alzheimer抯 disease; microglia; senile plaque; neurofibrillary tangle; inflammation
 
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