中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2008, 20(1): 29-
细胞膜表面单分子事件的实时观察
张筱敏,邱 爽,罗建红*
(浙江大学医学院,杭州310058)
摘 要:单分子实时检测以高分辨率显微镜及纳米操作技术为支撑,实现在微观世界单分子水平探索和阐明生命现象的本质,进而展现生命科学的全景。本文综述了近年来单分子成像和检测领域的技术进展,以及将这些技术和创新方法在活细胞膜表面单分子事件研究中的应用,如蛋白质扩散、蛋白折叠动力学、膜受体装配及近膜区囊泡运动等。
关键词:单分子事件;成像;检测;细胞膜
中图分类号:Q2-33  文献标识码:A
 
Visualization of single-molecule event on cell membrane
ZHANG Xiao-min, QIU Shuang, LUO Jian-hong*
(Zhejiang University School of Medicine, Hangzhou 310058, China)
Abstract: Based on high-resolution microscopy and nano-manipulation techniques, single molecule detection allows us to explore and illustrate life phenomenon from microscopic view, and to better understanding of the panorama of life sciences. We reviewed here the technique advances in single molecule visualization and detection, and as well as the application of these techniques and creative research mathods in single molecular events on cell membrane, such as membrane protein diffusion, protein unfolding kinetics, assembly of receptors, vesicle movement and so on.
Key words: single molecule events; visulization; detection; cell membrane
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2952883 位访问者,欢迎!