中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2004, (5): 305-
雄激素和雌激素受体药物筛选方法的研究进展
牟凌云, 王明伟*
中国科学院上海生命科学研究院药物研究所, 国家新药筛选中心,上海 201203
摘 要:雄激素和雌激素受体通过与相应激素特异性结合促进细胞分化和组织生长,发挥重要的生理功能,其功能失调可诱发多种疾病。雄激素和雌激素受体的选择性调节剂是治疗相关疾病的重要药物。基于基因组学、分子生物学、细胞生物学和生物信息学等最新研究成果而发展形成的实验技术或方法被用于新型雄激素和雌激素受体调节剂的筛选,显著加快了新药开发的进程。
关键词:雄激素受体; 雌激素受体; 选择性受体调节剂
 
Advances in drug screening methods relative to androgen and estrogen receptors
MOU Ling-Yun, WANG Ming-Wei*
The National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
Abstract: Androgen and estrogen stimulate cell differentiation and tissue growth through specific interactions with respective receptor (AR or ER), thereby playing critical roles in numerous physiological processes. Dysfunctions of either hormones or receptors lead to various diseases. Selective AR or ER modulators possess ideal pharmacological profiles in disease treatment. Based upon the latest developments in genomics, molecular biology, cellular biology and bioinformatics, etc., new technologies or experimental methods have been applied to screen novel selective AR or ER modulators and thus, significantly accelerated the pace of drug discovery. 
Key words:  androgen receptor; estrogen receptor; selective receptor modulator
 
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