中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2004, (1): 11-
乙酰胆碱酯酶(AChE)与β淀粉样肽(Aβ)的相互关系
金其煌,张学军
中国科学院上海生命科学研究院生物化学与细胞生物学研究所,上海 200031
摘 要:老年性痴呆症(Alzheimer{$39}s Disease, AD)是一种慢性的、进行性的神经系统退行性疾病。主要特征为各方面智力的损伤,包括学习记忆、语言、读写、行为,以及对周围环境的识别,最终可导致死亡。它有三大病理特征:(1)主要由b淀粉样肽(β-amyloid peptide, Aβ)沉积而成的淀粉样斑;(2)由高度磷酸化的Tau蛋白组成的神经纤维缠结;(3)神经元及神经突触的丢失。在AD疾病的发病机制及治疗的对策中,Aβ和乙酰胆碱酯酶(acetylcholinesterase, AChE)都有重要的作用。近年来对Aβ和AChE在AD疾病发生发展过程中相互作用的研究有了越来越多的报道。在此,作者对Aβ和AChE的关系作一综述。
关键词:乙酰胆碱酯酶;β淀粉样肽;Alzheimer{$39}s疾病;活性;聚集
 
The relation between acetylcholinesterase (AChE) and β amyloid peptide (Aβ)
JIN Qi-Huang, ZHANG Xue-Jun
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Alzheimer{$39}s disease (AD) is a chronic, slowly progressive neurodegenerative disorder with characteristic deterioration of intellectual capacity in various domains: learning and memory, language abilities, reading and writing, praxis, interaction with the environment, and finally lead to death. It has three pathological hallmarks, including amyloid plaques, neurofibrillary tangles and selective neuronal loss.  Both Aβ and AChE have an important role in physiopathology of AD and therapic methods for AD.  Recently accumulating articles reported the relation between AChE and Aβ.  Thus, it is necessary to review the relation.
Key words: acetylcholinesterase; β amyloid peptide; Alzheimer{$39}s disease; activity; assemble
 
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