中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2004, (1): 24-
真核生物锌转运体及其活性的调控
秦海宏,王福俤,郭俊生
第二军医大学军队卫生学教研室,上海 200433
摘 要:真核生物的锌内稳态是由其众多特异转运体协同转运来实现的。有两个锌转运体家族ZIP和CDF被相继发现。ZIP家族的主要功能是摄取锌,而CDF家族成员主要参与锌的外排及锌在细胞内的区室化以达到解毒或贮存的目的。锌可在转录水平和翻译水平调控两类转运体的活性以维持锌在细胞和生物体水平的内稳态。
关键词:ZIP;CDF;锌转运体 
 
Eukaryotic zinc transporters and their regulation
QIN Hai-Hong, WANG Fu-Di, GUO Jun-Sheng
Department of Military Hygiene, Second Military Medical University, Shanghai 200433, China
Abstract: Intracellular homeostasis for zinc is achieved through the coordinate regulation of specific transporters engaged in zinc influx, efflux, and intracellular compartmentalization.  Two families of transporters, the ZIP and CDF families, have been found to play important roles in zinc transport.  ZIP family transporters are mainly involved in cellular zinc influx. In contrast, CDF family members mediate zinc efflux out of cells or facilitate zinc into intracellular compartment for detoxification and storage.  The activity of many of these transporters is regulated in response to zinc through transcriptional and post-transcriptional mechanisms to maintain zinc homeostasis at both the cellular and organismal levels.
Key words: ZIP; CDF; zinc transporter 
 
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