中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2005, (4): 308-
CCL27的不同剪切机制及其功能差异
邵先安,熊思东*
复旦大学上海医学院免疫学系 教育部分子医学重点实验室 上海基因免疫与疫苗研究中心,上海 200032
摘 要:CCL27是一种CC型趋化因子,其配体为CCR10。由于mRNA剪切的不同,CCL27形成两种不同的分子,即经典CCL27和其变异体PESKY,前者含分泌肽,对活化CD4+T细胞有趋化作用,是皮肤炎症反应中扮演主要角色的趋化因子;后者含有核内定位序列,调控细胞骨架结构的重排,这一特性为该趋化因子所独有,可能预示着趋化因子家族的新功能。
关键词:CCL27;PESKY;剪切机制;功能
 
Differential splicing mechanism of CCL27 and distinct consequence
SHAO Xian-An, XIONG Si-Dong*
Department of Immunology of Shanghai Medical College of Fudan University, Key Laboratory of Molecular Medicine of Ministry of Education, Center for Gene Immunization and Vaccine Research, Shanghai 200032, China
Abstract: CC chemokine ligand 27 (CCL27), through interaction with its cognate receptor, CC chemokine receptor 10 (CCR10), involved in attracting a subset of CD4+ T cells to the skin during some cutaneous inflammatory responses. Strangely, CCL27 can also be produced as a non-secreted form, as a result of alternative splicing. This protein, termed PESKY, is targeted to the nucleus where it is able to modulate transcription and alter cell morphology. Specifically, PESKY induces a rearrangement of the actin cytoskeleton. Such character is sole in chemokine family and may foreshow new function of chemokine in immune response.
Key words: CCL27; PESKY; splicing mechanism; function
 
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