中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2005, (3): -
脑缺血/缺氧预适应引起的基因、蛋白质表达谱的变化
肖 亮,朱兴族*
中国科学院上海生命科学研究院上海药物研究所,中国科学院研究生院,上海 201203
摘 要:缺血/缺氧预适应保护作用的分子机制目前尚未充分阐明。最近的研究在大鼠和小鼠脑缺血/缺氧预适应的模型上采用了基因芯片、双向电泳结合质谱分析技术,揭示了大鼠和小鼠脑缺血/缺氧预适应引起的基因和蛋白质表达谱的变化。这些研究发现预适应引起一些新的基因和蛋白质的表达发生改变,深入研究这些基因和蛋白质有可能发现治疗脑中风新的药物靶标。
关键词:缺血/缺氧预适应; 脑; 基因组; 蛋白质组
 
Brain ischemic/hypoxic preconditioning induced alteration of genomic and proteomic expression
XIAO Liang, ZHU Xing-Zu*
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of CAS, Shanghai 201203, China
Abstract: Molecular mechanisms of neuroprotection induced by ischemic/hypoxic preconditioning are incompletely understood.  Recently, GeneChip analysis and two-dimensional gel electrophoresis combined with MALDI-TOF mass spectrum analysis were used to study alteration of genomic and proteomic expression induced by brain ischemic/hypoxic preconditioning in rats or mice.  Some new genes or proteins showing altered expression induced by brain ischemic/hypoxic preconditioning were identified.  Further studying the role of these genes and proteins in preconditioning might discover novel therapeutic targets for stroke.
Key words: ischemic/hypoxic preconditioning; brain; genome; proteome
 
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