中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2005, (3): 318-
人睾丸与脑基因表达谱的相似性
郭金虎, 赵寿元*
复旦大学生命科学院遗传工程国家重点实验室,上海 200433
摘 要:人类的物种形成与进化问题一直是研究的一个焦点。近年来,对于人和灵长类以及果蝇等其他一些动物多种组织基因表达谱的研究表明,在人的进化过程中脑基因表达的改变最为显著,并且脑中许多基因的表达呈显著上调。信息学分析显示,在多种组织当中,人的脑与睾丸可能存在最为相似的基因表达谱。这些结果提示睾丸可能与脑类似,也在人的物种形成和进化历程中起着重要作用。本文对人睾丸和脑基因表达谱的研究进行了回顾,并提出了该研究方向今后的一些研究设想。
关键词:脑;睾丸;基因表达谱;进化;现代智人
 
Similarity of gene expression patterns between human testis and brain
GUO Jin-Hu, ZHAO Shou-Yuan*
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China
Abstract: Issue regarding the Homo sapiens speciation and evolution has been intensively and extensively focused on. In recent years, investigations on the gene expression patterns of multiple tissues in diverse organisms including human, primates and fruit fly has been initiated, and the results indicated that the change of gene expression in human brain is the most significant during human evolution. Further analysis revealed that the gene expression in human brain was induced after human speciation. In addition, in silico studies demonstrated that among many tissues, human brain and testis exhibit a most similar gene expression pattern, suggesting testis might contribute to human speciation and evolution together with brain. Here I reviewed the previous work on the gene expression patterns of human brain and testis, and proposed some potential suggestions for future research.
Key words: brain; testis; gene expression pattern; evolution; Homo sapiens
 
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