中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2005, (3): 211-
抗幽门螺杆菌药物的研究进展
刘 青,王明伟*
中国科学院上海生命科学研究院上海药物研究所,国家新药筛选中心,上海201203
摘 要:幽门螺杆菌(Helicobacter pylori)是引起胃炎、胃和十二指肠溃疡乃至胃癌的主要致病菌。近年来,随着大量广谱抗生素的广泛应用使得耐药的幽门螺杆菌菌株呈不断上升趋势,开发高效和高选择性的抗幽门螺杆菌药物已经成为全球关注的课题。本文对近五年来文献报道的抗幽门螺杆菌药物和先导化合物分类进行简要综述,为研究开发幽门螺杆菌感染性疾病的治疗新药提供参考。
关键词:研究进展;抗幽门螺杆菌药物
 
Advances in studies on novel agents against icobacter pylori
LIU Qing, WANG Ming-Wei*
National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
Abstract: Helicobacter pylori is a well-recognized cause for gastritis, peptic ulcer and carcinoma of the stomach. With wide use of broad-spectrum antibiotics, drug-resistant strains of Helicobacter pylori have been emerged in a rapid pace. Development of highly efficacious and selective agents against Helicobacter pylori is thus becoming a focal point that attracts global attention. This article reviews a series of new drugs or lead candidates with inhibitory effects on Helicobacter pylori reported in the literature during recent five years, with an aim of providing some useful insights to research and development of novel drugs to treat Helicobacter pylori infection.
Key words: research progress; anti-Helicobacter pylori drugs
 
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