中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2005, 17(2): 147-
蛋白激酶AMPK的研究进展
符庆瑛,高钰琪*
第三军医大学病理生理学与高原生理学教研室,军队高原生理与高原病研究重点实验室,重庆 400038
摘 要:AMP激活的蛋白激酶(AMP-activated protein kinase, AMPK)广泛存在于真核细胞中,一旦被激活,即可磷酸化下游靶蛋白,关闭消耗ATP的合成代谢途径,开启产生ATP的分解代谢途径,被称为“细胞能量调节器”。许多新的下游靶蛋白的发现也为AMPK生物学效应的阐明提供了新思路。
关键词:AMPK;能量代谢;AMP
 
Advances in the studies of AMP-activated protein kinase
FU Qing-Ying, GAO Yu-Qi*
Key Laboratory of High Altitude Physiology and Mountain Sickness of PLA, Department of Pathophysiology and High Altitude Physiology, Third Military Medical University, Chongqing 400038, China
Abstract: The AMP-activated protein kinase is found in all eukaryotic cells. Once activated, the kinase switches on ATP-producing catabolic pathways and switches off ATP-consuming processes,both via direct phosphorylation of downstream targets, and thus is called a “cellular energy regulator”. A variety of novel downstream target proteins have been discovered recently, which provide new insight into elucidating precise functions of AMP-activated protein kinase.
Key words: AMP-activated protein kinase; energy metabolism; adenosine monophosphate
 
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